October 2, 2023
The article describes how new research suggests that fluoxetine (Prozac)—a widely used antidepressant that crosses the blood-brain barrier—may damage tumor cells and make them more sensitive to chemotherapy in patients with recurrent high-grade glioma. A new clinical trial called FLIrT will explore the effectiveness and safety of combining fluoxetine with temozolomide, using tumor samples from surgery to assess impact and guide future larger studies.
Dr. Khasraw and Kirit Singh will be leading the trial to test whether repurposing fluoxetine can enhance chemotherapy in aggressive brain tumors.
Read the full article here.